Angelika Lampert

This study demonstrates the generation of functional human sensory neurons from iPSCs using NBI factors, showing their electrophysiological properties and disease relevance.

This paper develops a standardized framework for generating sensory neurons from human iPSCs using NGN1, improving differentiation efficiency and functional maturation for disease modeling and drug screening.

This paper develops polyclonal iPSC strategies to generate clonally diverse sensory neurons, reducing workload and enabling scalable drug-screening and patient-in-a-dish applications.

The paper investigates the M899I variant in Nav1.7, showing it causes pore collapse, leading to loss of sodium currents and pain insensitivity.

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

The paper uses a renormalization group approach and machine learning to identify pain-disease-associated mutations in human NaV1.7 channels.

This study shows that cholesterol depletion alters Nav1.7 structure and function, affecting its gating and drug response, with implications for pain management.

The paper analyzes sex- and strain-specific chemical signals in mouse urine using VNO activity and molecular profiling to understand their discriminatory power and differences between inbred and wild mice.

The paper shows that uncoupling dimerized Nav1.7 channels reduces persistent current caused by a pain mutation, suggesting dimerization plays a role in pain syndromes.

The paper investigates voltage-gated sodium channels in rat neocortical pyramidal neurons and finds they exhibit Cole-Moore activation kinetics rather than traditional Hodgkin-Huxley kinetics.