Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis
Paba Edisuriya, Pramodha S. Liyanage, Jesun Lee, Ameet Shetty, Hongyu Liu, Nicholas P. Tatonetti, Danielle Hutchings, Alvin Jay Freeman, Jaimie D. Nathan, Appakalai N. Balamurugan, Stephen Jacob Pandol, Anil Goud Jegga, Anjaparavanda P. Naren, Kavisha Arora
This study identifies CFTR-related defects in idiopathic pancreatitis and shows that ivacaftor can reverse these defects in patient-derived models.
bioRxiv · May 25, 2025 · PreprintPathology