KDM6A knockout in human iPSCs alters the genome-wide histone methylation profile at active and poised enhancers, activating expression of ectoderm gene expression pathways.
Shailendra Shanker Maurya, Wei Yang, Qiang Zhang, Petra Erdmann-Gilmore, Amelia Bystry, Reid Townsend, Todd E. Druley
This study shows that KDM6A knockout in human iPSCs changes histone methylation at enhancers, leading to increased ectoderm gene expression.
bioRxiv · Mar 9, 2021 · PreprintGenomics