Shailendra Shanker Maurya

mTOR signaling regulates aberrant epithelial cell proliferative and migratory behaviors characteristic of airway mucous metaplasia in asthma

This study shows mTOR signaling drives aberrant epithelial behaviors in asthma, including proliferation and migration, and its inhibition reduces mucous metaplasia features.

KDM6A knockout in human iPSCs alters the genome-wide histone methylation profile at active and poised enhancers, activating expression of ectoderm gene expression pathways.

This study shows that KDM6A knockout in human iPSCs changes histone methylation at enhancers, leading to increased ectoderm gene expression.