Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques
Steven E. Bosinger, Christopher T Edwards, Kirti A. Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagné, Nadia Golden, Hadj Aoued, Kathryn Pellegrini, Matthew R. Burnett, Christopher Cole Honeycutt, Stacey A. Lapp, Thang Ton, Mark C. Lin, Metz Amanda, , Dennis R. Burton
This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.
PLoS Pathogens · Jan 23, 2025Peer-reviewedImmunology