Matthew Gagné

This study compares intranasal and intramuscular vaccines, finding that the intranasal Ad4-S vaccine provides more durable and effective immune responses against SARS-CoV-2 in preclinical models.

This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.

This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.