Steven E. Bosinger

Severity-stratified, longitudinal cis-eQTL mapping enables high-sensitivity detection of candidate causal genes for critical COVID-19

This paper identifies 23 candidate causal genes for critical COVID-19 by integrating severity-stratified, longitudinal cis-eQTL mapping with GWAS signals from 1,031 patients.

Germinal centers can persist for up to one year with declining somatic hypermutation and ongoing plasma cell output

This study tracks germinal center responses in rhesus macaques over a year, showing prolonged GCs with declining SHM and ongoing plasma cell production.

Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1

This paper develops a high-throughput method to identify and characterize neutralizing antibodies in vaccinated rhesus macaques, revealing key features of effective antibody responses.

Inhibition of Stemness Pathways during Acute SIV Limits Infection of Central Memory CD4+ T Cells and Alters Viral Reservoir Activity in Macaques

Co-delivered PD-L1 rescues the protective efficacy mediated by an AAV-expressed HIV-1 bNAb

This study shows that co-delivering PD-L1 with an AAV-expressed HIV-1 bNAb reduces anti-drug antibodies and improves bNAb expression and protection against HIV in rhesus macaques.

Overcoming host immune responses to an AAV-delivered HIV-1 bNAb in rhesus macaques mediated by co-delivery of PD-L1

This study shows that co-delivering PD-L1 with AAV-delivered bNAb 10-1074 reduces ADA responses and improves bNAb durability in rhesus macaques.

HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels

This study identifies that HIV-2 evades ZAP restriction through adaptations in the U3 LTR region despite having higher CpG levels compared to HIV-1 and SIVsmm.

Diverse priming outcomes under conditions of very rare precursor B cells

The paper investigates how vaccine antigen delivery and adjuvant selection affect the priming of rare HIV broadly neutralizing antibody-precursor B cells in non-human primates, finding that specific dosing and adjuvant combinations enhance their detection in germinal centers.

Identification of a multi-omics factor predictive of long COVID in the IMPACC study

The paper identifies a multi-omics recovery factor predictive of long COVID using data from the IMPACC study, showing it can predict LC risk early after infection.

Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques

This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.

A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques

The paper develops methodologies to generate and analyze immunoglobulin loci variation in rhesus macaques, revealing extensive diversity and expanding existing allele sets by 60%.

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping

This study identifies immune subtypes in hospitalized COVID-19 patients linked to clinical outcomes and long COVID risk through longitudinal multi-omics analysis.

Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19

This study investigates viral reactivation in COVID-19 patients, finding associations between reactivation of specific virus families and clinical outcomes, including mortality and PASC symptoms.

Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection

The paper shows that eosinophils protect against SARS-CoV-2 in vaccinated mice during breakthrough infections by reducing viral burden and limiting dissemination.

The Vacc-SeqQC Project: Benchmarking RNA-Seq for Clinical Vaccine Studies

This study benchmarks RNA-Seq technical parameters in a clinical vaccine trial to establish guidelines for future studies.

Alterations of redox and iron metabolism accompany development of HIV latency.

The paper identifies alterations in redox and iron metabolism associated with HIV-1 latency development and suggests iron metabolism modulators as potential therapeutic tools.