Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain
N.N. Nikitina, Jonathan Wadsworth, Matthew H. Goelzer, Madison Goldfeldt, Nurbanu Bursa, Sean Michael Howard, Chase Crandall, Amevi M. Semodji, Anamaria G. Zavala, Stefan Judex, Janet Rubin, Trevor J. Lujan, Clare K. Fitzpatrick, Clinton T. Rubin, Aykut Cihan Satici, Gunes Uzer
This study shows that low-intensity vibrations cause nuclear motion and cytoskeletal changes in mesenchymal stem cells, independent of matrix strain, leading to transcriptional activation.
bioRxiv · Apr 7, 2025 · PreprintBioengineering