Chronological Aging Stiffens Cells, Alters Mitochondria, and Impairs Mitochondrial Mechanical Responsiveness in Mesenchymal Stem Cells
Omar Faruq, N.N. Nikitina, Scott Birks, Calvin L. Jones, Matthew H. Goelzer, Sean Michael Howard, Anamaria G. Zavala, Nilufar Ali, Gunes Uzer
This study shows that aging impairs mesenchymal stem cells by reducing osteogenesis, increasing adipogenesis, and decreasing mitochondrial mechanical responsiveness.
bioRxiv · Feb 26, 2026 · PreprintBioengineering