SIK3 links synaptic strength to sleep pressure through RhoA signaling
Tomohiro Kitazono, Motoki Juichi, Kei Nishida, Shinnosuke Nomura, Chika Shimizu, Ami Kato, Yusuke Iino, Natsuki Higashide, Kazuya Miyanishi, Shinya Nakata, Natsumi Ageta‐Ishihara, Takeshi Sawada, Shoi Shi, Hiromasa Funato, Masashi Yanagisawa
This study shows SIK3 links synaptic strength to sleep pressure via RhoA signaling, with two opposing pathways affecting spine size and sleep delta density.
bioRxiv · Oct 1, 2026 · PreprintNeuroscience