Author

Yusuke Iino

Center for Disease Biology and Integrative Medicine, The University of TokyoORCID 0000-0002-5318-1840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Takeshi SawadaiD· 3 shared Chika Shimizu· 2 shared Mio Tajiri· 2 shared Sho YagishitaiD· 2 shared Shoi ShiiD· 2 shared Airi Inoue· 1 shared Ami Kato· 1 shared Haruo KasaiiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Takeshi SawadaORCID

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4 papers

Recent·Most cited

SIK3 links synaptic strength to sleep pressure through RhoA signaling

Tomohiro Kitazono, Motoki Juichi, Kei Nishida, Shinnosuke Nomura, Chika Shimizu, Ami Kato, Yusuke Iino, Natsuki Higashide, Kazuya Miyanishi, Shinya Nakata, Natsumi Ageta‐Ishihara, Takeshi Sawada, Shoi Shi, Hiromasa Funato, Masashi Yanagisawa

This study shows SIK3 links synaptic strength to sleep pressure via RhoA signaling, with two opposing pathways affecting spine size and sleep delta density.

bioRxiv · Oct 1, 2026 · PreprintNeuroscience

Reactivating a schizophrenia risk gene-enriched prefrontal ensemble suppresses decision noise

Yusuke Iino, Hiroto Narita, Chika Shimizu, Shoi Shi

The paper identifies a schizophrenia risk gene-enriched prefrontal ensemble that stabilizes decision-making and shows that reactivating it with a multi-receptor antagonist cocktail suppresses decision noise without sedation.

bioRxiv · Jun 17, 2026 · PreprintNeuroscience

Microglia regulate developmental transitions in synaptic plasticity rules in the medial prefrontal cortex

Mio Tajiri, Hidefumi Omi, Airi Inoue, Hayato Etani, Takeshi Sawada, Yusuke Iino, Sho Yagishita

This study shows microglia regulate the shift from Hebbian to three-factor plasticity rules in the medial prefrontal cortex during development, affecting social learning and pain sensitivity.

bioRxiv · Jun 16, 2025 · PreprintNeuroscience

The minimal behavioral time window for reward conditioning in the nucleus accumbens of mice

Kenji Yamaguchi, Yoshitomo Maeda, Takeshi Sawada, Yusuke Iino, Mio Tajiri, Ryosuke Nakazato, Shin Ishii, Haruo Kasai, Sho Yagishita

The paper identifies a 1-second time window for reward conditioning in the nucleus accumbens of mice, dependent on dopamine D1 receptor and CaMKII signaling.

Scientific Reports · Feb 4, 2022Peer-reviewedNeuroscience