Shoi Shi

This study shows SIK3 links synaptic strength to sleep pressure via RhoA signaling, with two opposing pathways affecting spine size and sleep delta density.

The paper identifies a schizophrenia risk gene-enriched prefrontal ensemble that stabilizes decision-making and shows that reactivating it with a multi-receptor antagonist cocktail suppresses decision noise without sedation.

The paper models mutation probability in Arabidopsis thaliana using epigenetic data, identifying combinatorial patterns that predict mutation-rate variation across coding sequences.

The paper identifies PKA and phosphatases as regulators of sleep-wake cycles through genetic and functional studies in mice.

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

This study uses surface temperature monitoring to visualize and analyze circadian rhythms in adults with jet lag and infants, showing circadian shifts and developmental progression.

The paper develops a framework to determine active connectivity in the mouse brain by combining experimental and computational methods to identify the most active neural networks during different times of the day.

This study shows that CaMKIIβ phosphorylation regulates sleep duration and steps in mammals by modulating kinase activity in excitatory neurons.

CUBIC-Cloud is a cloud-based framework for analyzing and integrating whole mouse brain data, demonstrating applications in cell distribution, plaque quantification, neuronal activity, and connectivity mapping.