Targeting DNA Methylation Reactivates Type I Interferon Signalling in Bone-Metastatic Breast Cancer
Joan So, Thomas B Chadwick, Miriam Fuentes, Laura Vojtech, Lap Hing Chi, Braydon A. Meyer, Ruth Pidsley, Nicole M. Haynes, Hugh Chalmers, Aliye Tabatabaee, Amina Ismail, Karla J. Cowley, Kaylene J. Simpson, Clare Stirzaker, Belinda S. Parker
This study identifies Decitabine as a DNA hypomethylating agent that reactivates type I interferon signalling in bone-metastatic breast cancer, reducing metastatic potential.
bioRxiv · Jun 29, 2026 · PreprintCancer Biology