Karla J. Cowley

The paper identifies WEE1, CDK1, and PLK1 as regulators of mRNA export during DNA replication stress, showing their role in preventing R-loop associated mRNA from being exported to the cytoplasm.

The paper identifies a druggable metabolite binding site in the FA E3 ligase complex that inhibits its activity and selectively kills BRCA1-deficient cells.

This study identifies Decitabine as a DNA hypomethylating agent that reactivates type I interferon signalling in bone-metastatic breast cancer, reducing metastatic potential.

This paper develops a large biobank of patient-derived MOC organoids and screens them for drug efficacy, finding resistance to standard therapies and effectiveness of less commonly used drugs.

This study identifies localized nucleolar surveillance mechanisms that respond to rDNA damage by activating the nucleolar DNA damage response (nDDR) through R-loop formation and RAD54L protection.

This paper introduces a consensus clustering method to identify robust signals from high-throughput screens by analyzing multi-scale data organization in cancer cell lines and bacterium models.