Kaylene J. Simpson

This paper identifies a synergistic combination of RNA Polymerase I inhibitor CX-5461 and CDK inhibitor Dinaciclib that enhances therapeutic efficacy in AML by inducing nucleolar stress and cell cycle arrest.

The paper identifies a druggable metabolite binding site in the FA E3 ligase complex that inhibits its activity and selectively kills BRCA1-deficient cells.

This study identifies Decitabine as a DNA hypomethylating agent that reactivates type I interferon signalling in bone-metastatic breast cancer, reducing metastatic potential.

This paper develops a large biobank of patient-derived MOC organoids and screens them for drug efficacy, finding resistance to standard therapies and effectiveness of less commonly used drugs.

This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.

This study identifies localized nucleolar surveillance mechanisms that respond to rDNA damage by activating the nucleolar DNA damage response (nDDR) through R-loop formation and RAD54L protection.

This study identifies JNK pathway suppression as a driver of resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer, with implications for patient stratification.

macpie streamlines analysis of high-throughput transcriptomic profiling data from plate-based screens using R, integrating preprocessing, quality control, and multimodal data integration.

This paper introduces a consensus clustering method to identify robust signals from high-throughput screens by analyzing multi-scale data organization in cancer cell lines and bacterium models.

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.