Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy response
Joaquín Araos Henríquez, Muntadher Jihad, Amir Jassim, Eloise G. Lloyd, Weike Luo, Judhell S. Manansala, Sneha Harish, Sara Pinto Teles, Priscilla S.W. Cheng, Gianluca Mucciolo, Wenlong Li, Marta Zaccaria, Debasmita Mukherjee, Rebecca J. Brais, Sally Mills, , Giulia Biffi
This study uses cross-species graph-embedding to show that ageing affects PDAC stroma and therapy response, identifying IRAK4 as a therapeutic target in aged PDAC models.
bioRxiv · Feb 3, 2026 · PreprintCancer Biology