Marta Zaccaria

This study shows that TGF-β-dependent myCAFs promote pancreatic cancer metastasis, while IL-1-dependent iCAFs do not, through distinct signaling mechanisms.

This study compares fibroblast heterogeneity in pancreatic cancer and pancreatitis using organoid co-cultures and identifies distinct stromal reprogramming in each condition.

This study uses cross-species graph-embedding to show that ageing affects PDAC stroma and therapy response, identifying IRAK4 as a therapeutic target in aged PDAC models.

This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.