Author

Joaquín Araos Henríquez

University of CambridgeORCID 0000-0002-0901-7672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Eloise G. LloydiD· 4 shared Gianluca MuccioloiD· 4 shared Giulia BiffiiD· 4 shared Marta ZaccariaiD· 4 shared Mireia VallespinósiD· 4 shared Muntadher JihadiD· 4 shared Priscilla S.W. ChengiD· 4 shared Sneha HarishiD· 4 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Eloise G. LloydORCID

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Author profile →

4 papers

Recent·Most cited

TGF-β- and IL-1-dependent fibroblast states differentially shape pancreatic cancer microenvironments and metastasis

Priscilla S.W. Cheng, Eloise G. Lloyd, Muntadher Jihad, Marta Zaccaria, Kristen Burgess, Gianluca Mucciolo, Sneha Harish, Weike Luo, Judhell S. Manansala, Wenlong Li, Joaquín Araos Henríquez, Debasmita Mukherjee, Sally Mills, Paul M Johnson, Alejandro Alonso Montero, , Giulia Biffi

This study shows that TGF-β-dependent myCAFs promote pancreatic cancer metastasis, while IL-1-dependent iCAFs do not, through distinct signaling mechanisms.

bioRxiv · Sep 10, 2026 · PreprintCancer Biology

Multi-stromal organoid co-cultures model pancreatic cancer and pancreatitis epithelial cell-fibroblast heterogeneity

Wenlong Li, Muntadher Jihad, Eloise G. Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S.W. Cheng, Sneha Harish, Sally Mills, Paul M Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca J. Brais, , Giulia Biffi

This study compares fibroblast heterogeneity in pancreatic cancer and pancreatitis using organoid co-cultures and identifies distinct stromal reprogramming in each condition.

Nature Cell Biology · Sep 2, 2026Peer-reviewedCancer Biology

Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy response

Joaquín Araos Henríquez, Muntadher Jihad, Amir Jassim, Eloise G. Lloyd, Weike Luo, Judhell S. Manansala, Sneha Harish, Sara Pinto Teles, Priscilla S.W. Cheng, Gianluca Mucciolo, Wenlong Li, Marta Zaccaria, Debasmita Mukherjee, Rebecca J. Brais, Sally Mills, , Giulia Biffi

This study uses cross-species graph-embedding to show that ageing affects PDAC stroma and therapy response, identifying IRAK4 as a therapeutic target in aged PDAC models.

bioRxiv · Feb 3, 2026 · PreprintCancer Biology

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

Eloise G. Lloyd, Muntadher Jihad, Judhell S. Manansala, Wenlong Li, Priscilla S.W. Cheng, Sara Pinto Teles, Gianluca Mucciolo, Joaquín Araos Henríquez, Sally Ashworth, Weike Luo, Sneha Harish, Paul M. Johnson, Lisa Veghini, Marta Zaccaria, Rebecca J. Brais, , Giulia Biffi

This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.

Cancer Research · Jan 21, 2025Peer-reviewedCancer Biology