Author

Sara Pinto Teles

University of CambridgeORCID 0000-0002-7409-9651Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Giulia BiffiiD· 3 shared Muntadher JihadiD· 3 shared Priscilla S.W. ChengiD· 3 shared Eloise G. LloydiD· 2 shared Gianluca MuccioloiD· 2 shared Joaquín Araos HenríqueziD· 2 shared Judhell S. ManansalaiD· 2 shared Marta ZaccariaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Giulia BiffiORCID

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3 papers

Recent·Most cited

IL-1-activated cancer-associated fibroblasts promote STAT1-driven transcriptional reprogramming of pancreatic tumour cells

Catarina Pelicano, Igor V. Chernukhin, Marleen Woelke, Priscilla S.W. Cheng, Lisa Young, Abigail R. Edwards, Elizabeth Mannion, Yi Cheng, Maureen Crowshaw, Steven Kupczak, Sara Pinto Teles, Muntadher Jihad, Kamal Kishore, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, , Shalini V. Rao

This paper shows that IL-1-activated cancer-associated fibroblasts (iCAFs) promote STAT1-driven transcriptional reprogramming in pancreatic tumour cells, leading to chemoresistance and identifying STAT1 as a therapeutic target.

bioRxiv · May 29, 2026 · PreprintCancer Biology

Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy response

Joaquín Araos Henríquez, Muntadher Jihad, Amir Jassim, Eloise G. Lloyd, Weike Luo, Judhell S. Manansala, Sneha Harish, Sara Pinto Teles, Priscilla S.W. Cheng, Gianluca Mucciolo, Wenlong Li, Marta Zaccaria, Debasmita Mukherjee, Rebecca J. Brais, Sally Mills, , Giulia Biffi

This study uses cross-species graph-embedding to show that ageing affects PDAC stroma and therapy response, identifying IRAK4 as a therapeutic target in aged PDAC models.

bioRxiv · Feb 3, 2026 · PreprintCancer Biology

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

Eloise G. Lloyd, Muntadher Jihad, Judhell S. Manansala, Wenlong Li, Priscilla S.W. Cheng, Sara Pinto Teles, Gianluca Mucciolo, Joaquín Araos Henríquez, Sally Ashworth, Weike Luo, Sneha Harish, Paul M. Johnson, Lisa Veghini, Marta Zaccaria, Rebecca J. Brais, , Giulia Biffi

This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.

Cancer Research · Jan 21, 2025Peer-reviewedCancer Biology