In silico reconstruction of primary and metastatic tumor architecture using GIS-augmented spatial transcriptomics
Jin Young Yoo, Sabrina Akter, Qianying Zuo, Amir Kazemi, Wenjun Wu, Mahima Goel, Audrey Lam, Debapriya Dutta, Betsy Barnick, Melike Pekmezci, Maria Grosse Perdekamp, Aiman Soliman, Zeynep Madak‐Erdogan
This paper introduces GIS-ROTA, a framework that integrates biological knowledge with spatial transcriptomics to identify functionally relevant spatial domains in breast tumors.
bioRxiv · Oct 16, 2025 · PreprintCancer Biology