Loss of ATP-sensitive channel expression and function decreases opioid sensitivity in a mouse model of type 2 diabetes
Cole Fisher, Kayla Johnson, Madelyn N. Moore, Amir Sadrati, Jody L. Janecek, Melanie L. Graham, Amanda H. Klein
This study shows that reduced KATP channel expression in diabetic mice decreases opioid sensitivity and antinociception, with partial recovery through SUR1 upregulation.
bioRxiv · Sep 6, 2023 · PreprintNeuroscience