Kayla Johnson

This study shows that loss of either SUR1 or Kir6.2 subunits in neurons increases dorsal root ganglion excitability and reduces morphine antinociception in mice.

This study shows that inhibiting AC1 and EPAC restores KATP channel activity after chronic opioid exposure, reducing morphine tolerance and withdrawal.

This study shows that reduced KATP channel expression in diabetic mice decreases opioid sensitivity and antinociception, with partial recovery through SUR1 upregulation.

This study shows reducing Adenylyl Cyclase 1 activity decreases morphine-induced hyperalgesia and inflammatory pain in mice without affecting morphine's analgesic effects.

This study investigates the role of SUR1-subtype KATP channels in opioid-induced antinociception and hyperlocomotion, finding attenuated antinociception and potentiated hyperlocomotion in SUR1-deficient mice.