Author

Madelyn N. Moore

University of MinnesotaORCID 0000-0001-8008-5275Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Amanda H. KleiniD· 2 shared Abigail R. AlwiniD· 1 shared Amir Sadrati· 1 shared Asuka InoueiD· 1 shared Campbell L. KrusemarkiD· 1 shared Caroline Ray· 1 shared Cole FisheriD· 1 shared Ezequiel Marrón Fernández de VelascoiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Amanda H. KleinORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologyNaturePeer-reviewedOct 22, 2025

Design of allosteric modulators that change GPCR G protein subtype selectivity

Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto…·Lauren M. Slosky

This study designs allosteric modulators that alter GPCR G protein subtype selectivity by targeting the receptor-transducer interface, demonstrating predictable mechanisms for rational drug design.

29 citationstop 1%

humanproteomics

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NeurosciencebioRxivPreprintSep 6, 2023

Loss of ATP-sensitive channel expression and function decreases opioid sensitivity in a mouse model of type 2 diabetes

Cole Fisher, Kayla Johnson, Madelyn N. Moore…·Amanda H. Klein

This study shows that reduced KATP channel expression in diabetic mice decreases opioid sensitivity and antinociception, with partial recovery through SUR1 upregulation.

3 citations

mousestatistical model

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NeuroscienceMolecular PainPeer-reviewedJan 1, 2021

Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain

Travis Okerman, Taylor Jurgenson, Madelyn N. Moore, Amanda H. Klein

This study shows that inhibiting the PI3K-AKT-cGMP-JNK pathway reduces morphine tolerance in a mouse model of neuropathic pain.

10 citations

mousebulk RNA-seq

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