Melanie L. Graham

Spatial Transcriptomics Reveals Compartment-Specific Immune Activation Signatures in Ileal and Lymph Node Tissue in Treated HIV Infection

This study uses spatial transcriptomics to identify compartment-specific immune activation signatures in ileal and lymph node tissues of HIV-treated patients, revealing tissue-specific transcriptional differences linked to immune activation and microbial translocation.

Plasma metabolomics reveals lipid-predominant metabolic disruptions in virologically suppressed people with HIV

The paper uses metabolomics to show that HIV-treated individuals have metabolic disruptions, including lipid changes and inflammation markers, despite viral suppression.

Multi-omics links microbial dysbiosis, systemic inflammation and metabolomic disruptions to SNAE risk in treated HIV

This study links microbial dysbiosis, systemic inflammation, and metabolomic disruptions to SNAE risk in treated HIV patients through multi-omic analysis.

Loss of ATP-sensitive channel expression and function decreases opioid sensitivity in a mouse model of type 2 diabetes

This study shows that reduced KATP channel expression in diabetic mice decreases opioid sensitivity and antinociception, with partial recovery through SUR1 upregulation.

Mucosal microbiota and metabolome along the intestinal tracts reveals location specific relationship

The paper analyzes mucosal microbiota and metabolome in non-human primates to identify location-specific microbial signatures and their relationship with host tissue metabolites.