Human AUTS2 regulates neurodevelopmental pathways via dual DNA/RNA binding.
Verônica Monteiro Saia-Cereda, Amandeep Sharma, Keegan Flanagan, Sara Elmsaouri, Sheila Steiner, Simone K. Benassi, Guilherme Reis‐de‐Oliveira, Jack T. Whiteley, Amoolya Chandrabhatta, Ana Paula Diniz Mendes, Lynne Randolph‐Moore, Dimitra Xenitopoulos, Milla Jetzer, Ruth Oefner, Christopher W. Benner, , Maria Carolina Marchetto
This study identifies AUTS2's dual DNA/RNA binding in human neural progenitors and shows its role in regulating Wnt pathway genes, linking its disruption to neurodevelopmental disorders.
bioRxiv · Oct 7, 2025 · PreprintNeuroscience