Inhibition of the Lysosomal Amino Acid Sensor SLC38A9 by the Membrane Microprotein SPAR
Ampon Saeher, Xuelang Mu, Tamir Gonen
This study identifies SPAR, a microprotein, as an inhibitor of SLC38A9, a lysosomal amino acid transporter, revealing its role in mTORC1 pathway regulation by blocking arginine transport and Rag GTPase recruitment.
bioRxiv · Aug 10, 2026 · PreprintBiochemistry