Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance
Ellen L. Shrock, Eric Sun, Amrita Dhindsa, Max H. Witwer, Zhou Yu, Danton Ivanochko, I‐Hsiu Lee, Brian Coventry, Maria Borras Gonzalez, Jean‐Philippe Julien, Stephen Joseph Elledge, David A. Baker
This study identifies germline-encoded features as the primary driver of immunodominance in antibody responses to SARS-CoV-2, using structural modeling and mutational analysis.
bioRxiv · Jun 4, 2026 · PreprintImmunology