Author

Max H. Witwer

Howard Hughes Medical InstituteORCID 0009-0007-9520-9163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

David A. BakeriD· 2 shared Amrita Dhindsa· 1 shared Bingxu LiuiD· 1 shared Brian CoventryiD· 1 shared Danton IvanochkoiD· 1 shared Ellen L. ShrockiD· 1 shared Eric Sun· 1 shared I‐Hsiu LeeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

David A. BakerORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintOct 27, 2026

Function-preserving CD8⁺ T Cell Immunogenicity minimization through protein design

Bingxu Liu, Tianyang Mao, Max H. Witwer…·David A. Baker

The paper develops a computational framework to minimize CD8⁺ T cell immunogenicity in designed proteins while preserving function, using a de novo luciferase as a model.

DOI 10.64898/2026.10.24.761497

mouseprotein sequence

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 4, 2026

Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance

Ellen L. Shrock, Eric Sun, Amrita Dhindsa…·David A. Baker

This study identifies germline-encoded features as the primary driver of immunodominance in antibody responses to SARS-CoV-2, using structural modeling and mutational analysis.

DOI 10.64898/2026.06.02.729678

humanscRNA-seq

𝕏 PostBluesky