Author

Ellen L. Shrock

Brigham and Women's HospitalORCID 0000-0003-2484-4374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

David A. BakeriD· 2 shared Amrita Dhindsa· 1 shared Andrew J. BorstiD· 1 shared Basile I. M. WickyiD· 1 shared Benedikt SingeriD· 1 shared Brian CoventryiD· 1 shared Buwei HuangiD· 1 shared Cameron CriswelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

David A. BakerORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 4, 2026

Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance

Ellen L. Shrock, Eric Sun, Amrita Dhindsa…·David A. Baker

This study identifies germline-encoded features as the primary driver of immunodominance in antibody responses to SARS-CoV-2, using structural modeling and mutational analysis.

DOI 10.64898/2026.06.02.729678

humanscRNA-seq

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BioengineeringNaturePeer-reviewedNov 5, 2025

Atomically accurate de novo design of antibodies with RFdiffusion

Nathaniel R. Bennett, Joseph L. Watson, Robert J. Ragotte…·David A. Baker

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

381 citationstop 1%

protein structuredeep learning

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