Drug resistance through ribosome splitting and rRNA disordering in mycobacteria
Soneya Majumdar, Amuliya Kashyap, Ravi Kiran Koripella, Manjuli Rani Sharma, Kelley R. Hurst-Hess, Swati R. Manjari, Nilesh K. Banavali, Pallavi Ghosh, Rajendra Kumar Agrawal
This study reveals how mycobacterial HflX mediates ribosome splitting and antibiotic resistance through rRNA disordering and anti-association mechanisms.
Proceedings of the National Academy of Sciences · Feb 6, 2025Peer-reviewedBiochemistry