Nilesh K. Banavali

The paper analyzes how medically important antimicrobials bind to the 30S ribosomal subunit of Borrelia burgdorferi using structural analogy and computational methods to predict binding free energy.

This paper designs a PPI inhibitor peptide that activates PTP1B by disrupting its interaction with the 14-3-3ζ complex, leading to reduced EGFR phosphorylation and cancer cell viability.

This study reveals how mycobacterial HflX mediates ribosome splitting and antibiotic resistance through rRNA disordering and anti-association mechanisms.

This study identifies a novel actinobacteria-specific ribosome tunnel occlusion factor in Mtb that blocks nascent polypeptide exit and interferes with drug binding during ribosome hibernation.

This study identifies genetic and metabolic adaptations in pan-drug resistant Candida auris strains that enable resistance without fitness costs.

This study identifies how mycobacterial Rsh detects deacylated tRNA in translating ribosomes through structural and functional analysis, revealing its constitutive surveillance mechanism.

The paper studies the role of two conserved histidines in the intein splicing of SufB in Mycobacterium tuberculosis, showing their impact on splicing and cleavage rates.

The paper analyzes the extent of B-form structure in a 6S RNA variant that mimics DNA to bind to Escherichia coli RNA polymerase using conformational distance from canonical A-form and B-form structures.