HIV-1 Rebound Virus Consists of a Small Number of Lineages That Entered the Reservoir Close to ART Initiation
Lynn Tyers, Matthew Moeser, Jean Felistas Ntuli, Shuntai Zhou, E. Spielvogel, Amy Sondgeroth, Craig H. Adams, Ruwayhida Thebus, Anna Yssel, Salim S. Abdool Karim, Nigel Garrett, Sergei L. Kosakovsky Pond, Carolyn E. Williamson, Ronald I. Swanstrom, Melissa-Rose Abrahams, Sarah Joseph
The paper identifies that HIV-1 rebound virus primarily originates from a small number of lineages that entered the reservoir near ART initiation, despite the reservoir containing older sequences.
bioRxiv · Jan 29, 2025 · PreprintMicrobiology