Author

Melissa-Rose Abrahams

University of Cape TownORCID 0000-0002-1907-4929Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Carolyn E. WilliamsoniD· 2 shared Matthew MoeseriD· 2 shared Nigel GarrettiD· 2 shared Ronald I. SwanstromiD· 2 shared Sarah JosephiD· 2 shared Adrian R. MartineauiD· 1 shared Amy Sondgeroth· 1 shared Andrew D. ReddiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPathology

Carolyn E. WilliamsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women

Sherazaan D. Ismail, Shorok Sebaa, Bianca Abrahams, Martha Nason, Mitchell J. Mumby, Jimmy Dimitrios Dikeakos, Sarah Joseph, Matthew Moeser, Ronald I. Swanstrom, Nigel Garrett, Carolyn E. Williamson, Thomas C. Quinn, Melissa-Rose Abrahams, Andrew D. Redd

This study investigates how HIV-1 Nef's ability to downregulate MHC-I affects the size of the replication-competent viral reservoir in South African women on ART, finding a significant association between MHC-I downregulation and reservoir size.

Journal of Virology · Jun 24, 2025Peer-reviewedPathology

Digital PCR detection of Mycobacterium tuberculosis and HIV-1 co-localization in spinal tuberculosis biopsies

Robyn Waters, Adrian R. Martineau, Maritz Laubscher, Robert Neil Dunn, Michael F. G. Held, Melissa-Rose Abrahams, Anna K. Coussens

The paper uses ddPCR to detect and quantify Mtb and HIV-1 in spinal tuberculosis biopsies, finding reciprocal relationships between pathogen abundance and immune microenvironment factors.

bioRxiv · Jun 11, 2025 · PreprintMicrobiology

HIV-1 Rebound Virus Consists of a Small Number of Lineages That Entered the Reservoir Close to ART Initiation

Lynn Tyers, Matthew Moeser, Jean Felistas Ntuli, Shuntai Zhou, E. Spielvogel, Amy Sondgeroth, Craig H. Adams, Ruwayhida Thebus, Anna Yssel, Salim S. Abdool Karim, Nigel Garrett, Sergei L. Kosakovsky Pond, Carolyn E. Williamson, Ronald I. Swanstrom, Melissa-Rose Abrahams, Sarah Joseph

The paper identifies that HIV-1 rebound virus primarily originates from a small number of lineages that entered the reservoir near ART initiation, despite the reservoir containing older sequences.

bioRxiv · Jan 29, 2025 · PreprintMicrobiology