Variation in enhancer activity across brain regions defines neurological disease risk and shapes cellular pathology
Hannah K. Ramcharan, Yasmine N. Sami, Kathryn Hazel, Chidera Okeke, Zia Barnard, An T. Hoang, Scott McCallum, Chesna Apere, Wenjuan Du, Megan Madden, Yike Huang, Xochitl Luna, Gesmira Molla, Deborah C. Mash, Olivia Corradin
The paper identifies brain region-specific enhancers linked to neurological disease risk and shows their role in cellular pathology using enhancer activity data and GWAS integration.
bioRxiv · Sep 22, 2026 · PreprintGenetics