Richard C. Sallari

Heterogeneous epigenetic variation converges on splicing dysregulation in opioid addiction

This study identifies epigenetic variation linked to opioid overdose using H3K27ac profiling and machine learning, revealing splicing dysregulation and CELF5 as a key factor.

Oncogenic reactivation of young L1s is a hallmark of colon cancer

The paper identifies oncogenic reactivation of young L1 transposable elements in colon cancer, showing PLZF loss drives this activity independently of cell division.

Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid dependence

The paper identifies case-specific epigenetic alterations in opioid dependence using ChIP-seq and Hi-C, revealing convergent regulatory loci associated with genetic and environmental risk factors.

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancer

The paper identifies driver genes in prostate cancer by analyzing convergence of non-coding mutations in regulatory regions using 3D chromatin interactions and genomic data.