Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1
Jun Pan, Xinyu Tong, Yuming Ding, Chao Lei, Shulin Wei, An Xu, Yaxuan Han, Qunnan Qiu, Huilin Pang, Xiaolong Hu, Chengliang Gong, Min Zhu
The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.
bioRxiv · Apr 17, 2024 · PreprintImmunology