Tirzepatide attenuates atherosclerosis through weight loss-independent anti-inflammatory mechanisms
Shuo Chen, Shulin Wei, Tian Tian, Z.H. Liu, Meiming Su, Fan-shun Zhang, Yanjun Yin, Meijie Chen, Lu Jiang, Paul Charles Evans, Bradford C. Berk, Stefan Offermanns, Yihai Cao, Zhihua Wang, Jianping Weng, Suowen Xu
This paper shows tirzepatide reduces atherosclerosis independently of weight loss by directly targeting vascular inflammation through the cAMP/PKA/eNOS pathway.
bioRxiv · Jun 29, 2026 · PreprintPhysiology