Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS
Tiana M. Scott, Lydia M. Arnold, Jordan A. Powers, D. A. McCann, Ana B. Rowe, Devin E. Christensen, Miguel J. B. Pereira, Wen Zhou, Rachel M. Torrez, Janet Iwasa, Philip J. Kranzusch, Wesley I. Sundquist, Jarrod S. Johnson
The paper shows that HIV-1 capsids protect reverse-transcribed DNA from cGAS detection, and that disrupting the capsid enhances cGAS activity.
PLoS Pathogens · Jan 28, 2025Peer-reviewedMicrobiology