Wen Zhou

The paper identifies BAF as a barrier that restricts TREX1 access to micronuclei, explaining the need for ER-tethering to enable TREX1 entry and suppress cGAS activation.

The paper shows that HIV-1 capsids protect reverse-transcribed DNA from cGAS detection, and that disrupting the capsid enhances cGAS activity.

This study shows that TREX1 mutations in the polyproline motif destabilize the protein, leading to excessive cGAS-STING signaling and autoimmune disease.