Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice
Miguel C. Santoscoy, Paula Espinoza, Killian S. Hanlon, Luna Yang, Lisa Nieland, Carrie Ng, Christian E. Badr, Suzanne E. Hickman, Demitri de la Cruz, Ana Griciuc, Joseph B. El Khoury, Rachel E. Bennett, Shiqian Shen, Casey A. Maguire
The paper identifies an AAV capsid, MC5, that efficiently and specifically transduces microglia via direct and intracerebroventricular injection in mice.
bioRxiv · Sep 25, 2024 · PreprintBioengineering