Lisa Nieland

Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion

This study uses human brain organoids to show that glioblastoma cells adopt neuron-like states and interact with region-specific synaptic inputs to drive invasion.

Lead (Pb) exposure alters neural cell fate in the developing human brain

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity

This study shows that delivering 4-1BBL via AAV enhances IL-12-induced anti-glioblastoma immunity in mouse models by boosting CD8 T cell activity and survival.

Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice

The paper identifies an AAV capsid, MC5, that efficiently and specifically transduces microglia via direct and intracerebroventricular injection in mice.