Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer's disease models
Camila C. Portugal, Evelyn C. S. Santos, Ana M. Pacheco, Sara Costa-Pinto, Tiago O. Almeida, Joana Tedim-Moreira, Dora Gavin, Teresa Canedo, Fabiana Oliveira, Teresa Summavielle, Sandra H. Vaz, Renato Socodato, João B. Relvas
This study shows that increasing SVCT2 in microglia reduces amyloid plaques, improves synaptic plasticity, and enhances memory in Alzheimer's disease models.
bioRxiv · Feb 29, 2024 · PreprintNeuroscience