Author

Camila Cabral Portugal

Universidade do PortoORCID 0000-0002-1093-6545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Teresa SummavielleiD· 6 shared Ana MagalhãesiD· 5 shared Renato SocodatoiD· 5 shared Teresa CanedoiD· 5 shared João Bettencourt RelvasiD· 4 shared Tiago O. AlmeidaiD· 4 shared Joana Tedim-MoreiraiD· 3 shared Renata L. AlvesiD· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersNeuroscience

Teresa SummavielleORCID

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6 papers

Recent·Most cited

Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer's disease models

Camila C. Portugal, Evelyn C. S. Santos, Ana M. Pacheco, Sara Costa-Pinto, Tiago O. Almeida, Joana Tedim-Moreira, Dora Gavin, Teresa Canedo, Fabiana Oliveira, Teresa Summavielle, Sandra H. Vaz, Renato Socodato, João B. Relvas

This study shows that increasing SVCT2 in microglia reduces amyloid plaques, improves synaptic plasticity, and enhances memory in Alzheimer's disease models.

bioRxiv · Feb 29, 2024 · PreprintNeuroscience

Rac1 signaling in microglia is essential for synaptic proteome plasticity and experience-dependent cognitive performance

Renato Socodato, Tiago O. Almeida, Camila Cabral Portugal, Evelyn Cristina da Silva Santos, Joana Tedim-Moreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhães, António Francisco Ambrósio, Cord Brakebusch, BORIS Y. RUBINSTEIN, Irina Sousa Moreira, Teresa Summavielle, Inês Mendes Pinto, João Bettencourt Relvas

This study shows Rac1 in microglia is crucial for synaptic proteome plasticity and cognitive performance through homeostatic regulation and synapse communication.

bioRxiv · Oct 18, 2021 · PreprintNeuroscience

Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine

Teresa Canedo, Camila Cabral Portugal, Renato Socodato, Tiago Oliveira Almeida, Ana Filipa Terceiro, Joana Bravo, Ana Isabel Silva, João Duarte Magalhães, Sónia Guerra‐Gomes, João Filipe Oliveira, Nuno Sousa, Ana Magalhães, João Bettencourt Relvas, Teresa Summavielle

This study shows that Meth exposure causes microglia reactivity through astrocyte-derived TNF and glutamate, affecting behavior in adult mice.

Neuropsychopharmacology · Aug 16, 2021Peer-reviewedNeuroscience

Altered environmental perception by parental stress and depression vulnerability: impact on mothers and offspring

Renata L. Alves, Camila Cabral Portugal, Igor Moreira Lopes, Pedro Oliveira, Cecília Juliana Alves, Fernando Barbosa, Teresa Summavielle, Ana Magalhães

The paper investigates how maternal stress affects maternal behavior and offspring cognition in rats with different depression vulnerability, finding differential impacts on oxytocin levels and cognitive outcomes.

bioRxiv · Feb 23, 2021 · PreprintNeuroscience

Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior

Renato Socodato, Joana F. Henriques, Camila Cabral Portugal, Tiago O. Almeida, Joana Tedim-Moreira, Renata L. Alves, Teresa Canedo, Cátia Silva, Ana Magalhães, Teresa Summavielle, João Bettencourt Relvas

This study shows that alcohol intake causes excessive synaptic pruning by microglia, leading to synapse loss and anxiety-like behavior.

Science Signaling · Sep 22, 2020Peer-reviewedNeuroscience

Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration

Renato Socodato, Camila Cabral Portugal, Teresa Canedo, Artur Rodrigues, Tiago O. Almeida, Joana F. Henriques, Sandra Henriques Vaz, João Duarte Magalhães, Cátia M. Silva, Filipa I. Baptista, Renata L. Alves, Vanessa Coelho‐Santos, Ana Paula Silva, Roberto Paes‐de‐Carvalho, Ana Magalhães, , João Bettencourt Relvas

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.

Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience