Author

Anabel Withy

The University of Sydney

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. HoyiD· 1 shared Lake‐Ee QuekiD· 1 shared Mariam F. Hakeem-Sanni· 1 shared Masih GhasemiiD· 1 shared Nancy T. SantiappillaiiD· 1 shared Xiangwen C Kong· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

Andrew J. HoyORCID

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1 paper

Recent·Most cited

Capacity-Contribution Paradox: Fatty Acid Oxidation Compensates for Low Glucose-Derived Acetyl-CoA in Cancer.

Nancy T. Santiappillai, Xiangwen C Kong, Mariam F. Hakeem-Sanni, Masih Ghasemi, Anabel Withy, Lake‐Ee Quek, Andrew J. Hoy

This study reveals that fatty acid oxidation (FAO) in cancer cells primarily compensates for low glucose-derived acetyl-CoA by supporting mitochondrial metabolism through a malic enzyme-dependent shunt, rather than serving as a primary fuel source.

bioRxiv · Mar 25, 2024 · PreprintCancer Biology