Andrew J. Hoy

The paper identifies distinct glutamine metabolism in a subset of proliferating cells using pathway-centric metabolomic analysis of cancer and non-cancer cell lines.

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

This study reveals that fatty acid oxidation (FAO) in cancer cells primarily compensates for low glucose-derived acetyl-CoA by supporting mitochondrial metabolism through a malic enzyme-dependent shunt, rather than serving as a primary fuel source.

The paper shows that CPT1a regulates the uptake of extracellular fatty acids into mitochondria for cardiolipin remodeling in prostate cancer cells, despite these fatty acids being minor contributors to the TCA cycle.