Author

Nancy T. Santiappillai

The University of SydneyORCID 0000-0001-9797-559XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Andrew J. HoyiD· 2 shared Lake‐Ee QuekiD· 2 shared Mariam F. Hakeem-Sanni· 2 shared Anabel Withy· 1 shared Jean Yee Hwa YangiD· 1 shared Masih GhasemiiD· 1 shared Xiangwen C Kong· 1 shared Yue CaoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

Andrew J. HoyORCID

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2 papers

Recent·Most cited

Cancer BiologyMolecular Systems BiologyPeer-reviewedJun 5, 2025

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells

Nancy T. Santiappillai, Yue Cao, Mariam F. Hakeem-Sanni…·Andrew J. Hoy

The paper identifies distinct glutamine metabolism in a subset of proliferating cells using pathway-centric metabolomic analysis of cancer and non-cancer cell lines.

7 citations

humanmetabolomics

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Cancer BiologybioRxivPreprintMar 25, 2024

Capacity-Contribution Paradox: Fatty Acid Oxidation Compensates for Low Glucose-Derived Acetyl-CoA in Cancer.

Nancy T. Santiappillai, Xiangwen C Kong, Mariam F. Hakeem-Sanni…·Andrew J. Hoy

This study reveals that fatty acid oxidation (FAO) in cancer cells primarily compensates for low glucose-derived acetyl-CoA by supporting mitochondrial metabolism through a malic enzyme-dependent shunt, rather than serving as a primary fuel source.

1 citation

humanmetabolomics

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