Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance
Annapurna Gupta, Fouad Choueiry, Jesse J. Reardon, Nikhil Pramod, Anagh Kulkarni, Eswar Shankar, Steven T. Sizemore, Daniel G. Stover, Jiangjiang Zhu, Bhuvaneswari Ramaswamy, Sarmila Majumder
This study identifies silencing of ASS1 and upregulation of nucleotide biosynthesis as mechanisms of tamoxifen resistance in invasive lobular carcinoma.
Cell Death and Disease · Jul 11, 2025Peer-reviewedCancer Biology