Jiangjiang Zhu

SWELL1 channel-mediated D-2HG export promotes immune evasion and metabolic fitness in IDH-mutant gliomas

This study identifies SWELL1-mediated D-2HG export as a mechanism for immune evasion and metabolic fitness in IDH-mutant gliomas, showing that inhibiting this pathway can suppress tumor growth and enhance immune response.

Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer

This study examines epigenetic, microbiome, and immune differences in early-onset colorectal cancer (EOCRC) compared to average-onset CRC, finding accelerated epigenetic aging and stronger immune-microbe correlations in EOCRC.

Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival

This study identifies Candida albicans colonization in colorectal tumors as a factor linked to reduced survival and impaired radiation response.

Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance

This study identifies silencing of ASS1 and upregulation of nucleotide biosynthesis as mechanisms of tamoxifen resistance in invasive lobular carcinoma.

Mapping Pesticide-Induced Metabolic Alterations in Human Gut Bacteria

This study maps pesticide-induced metabolic alterations in human gut bacteria by linking pesticides to specific microbial species and metabolic changes.

An explainable graph neural framework to identify cancer-associated intratumoral microbial communities

This paper introduces MICAH, a graph neural network framework that identifies cancer-associated microbial communities in intratumoral microbiome data across five cancer types.

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset

The paper introduces MEGA, a tool to identify cancer-associated microbes using RNA-seq data from the ORIEN dataset, leveraging graph attention networks and microbial community information.