Estrogen Signaling During Abrupt Involution Leads to Long-Term Metabolic Dysfunction Similar to Estrogen Receptor Negative Breast Cancer
Kate Ormiston, Neelam Shinde, Gautam Sarathy, Allen Zhang, Morgan Bauer, Rajni Kant Shukla, Sara Alsammerai, Annapurna Gupta, Djawed Bennouna, Julia Wesolowski, Xiaoli Zhang, Rachel E. Kopec, Eswar Shankar, Kristin I. Stanford, Ramesh Kumar Ganju, , Daniel G. Stover
This study compares abrupt and gradual involution in mouse mammary glands, finding that abrupt involution leads to metabolic dysfunction resembling estrogen receptor negative breast cancer.
bioRxiv · Oct 9, 2025 · PreprintCancer Biology