Daniel G. Stover

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

CNSigs identifies copy number mutational signatures across cancers, revealing associations with survival and treatment response.

This study develops multidimensional in vitro models to investigate anti-estrogen resistance and dormancy in invasive lobular carcinoma, identifying p27Kip1 signaling as central to dormant phenotype.

This study compares abrupt and gradual involution in mouse mammary glands, finding that abrupt involution leads to metabolic dysfunction resembling estrogen receptor negative breast cancer.

This study identifies silencing of ASS1 and upregulation of nucleotide biosynthesis as mechanisms of tamoxifen resistance in invasive lobular carcinoma.

FinaleMe predicts DNA methylation and tissues-of-origin from plasma whole-genome sequencing by using a non-homogeneous Hidden Markov Model.

MAESTRO enables efficient and accurate tracking of thousands of low-frequency mutations with reduced sequencing, improving mutation testing in cancer and liquid biopsies.